People with Crohn’s and colitis sometimes suffer from “extra-intestinal manifestations” or conditions that affect areas outside of the intestines. These include the eyes, mouth, blood, joints, bones, skin and liver.

Flare-ups of extra-intestinal manifestations do not necessarily correlate to flare-ups of Crohn’s and colitis. Sometimes they appear when intestinal problems are in remission; other times they can be in remission when the gut problems are active. There is also no guarantee that someone with Crohn’s or colitis will experience these problems; some people may never have extra-intestinal manifestations.

Blood Abnormalities

Some people with Crohn’s and colitis have an increased tendency to develop blood clots. For a variety of different reasons, those with Crohn’s and colitis are predisposed to forming clots in their veins, particularly during periods of inactivity. It is very important during periods of bed rest to “pump” the feet and move the legs to prevent clots forming in the calves. In addition, it is a good idea to get up out of bed and move around a little, even though the desire to stay hunkered down in the sheets is a strong one.

Eye Inflammation

Occasionally people with Crohn’s and colitis experience inflammation in their eyes. The inflammation can affect different parts of the eye, resulting in mild symptoms such as redness, some burning sensation and tearing, to more severe symptoms such as blurred vision, headache and eye pain. If any of these symptoms appear, it is best to see your physician.

Joint Inflammation

When joints become inflamed and painful due to intestinal complications, the medical term used is “enteropathic arthropathy” or EA. “Entero” means “intestinal”; “enteropathic” means disease caused by, or related to, the intestines.” “Arthropathy” means a disease of the joints.

Like non-enteropathic arthropathy, joint inflammation is experienced by redness, heat, pain, swelling and stiffness of the joints. Sounds like arthritis, doesn’t it? In fact, many patients describe it as arthritis to their doctors, and if it weren’t for their Crohns or colitis, their physicians would have diagnosed it as such.

The big difference with EA as opposed to arthritis is that it is non-destructive, and the swelling and pain are usually temporary with no damage to joints after a flare-up. Oddly enough, arthralgia (joint pain) can occur separate from intestinal flare-ups; the patterns are quite variant and inconsistent.

EA often affects the large joints such as the hips and knees, but can sometimes attack the small joints of the fingers and toes.

Liver Trouble

Up to 5% of Crohn’s and colitis patients develop primary sclerosing cholangitis (PSC). PSC is more typically associated with ulcerative colitis than Crohn’s disease. This serious liver disease results from inflammation of the small vessels that transport bile from the liver to the small bowel. If the condition becomes severe, it can cause damage to the liver and potentially liver failure. If you have Crohn’s or colitis and you develop a fever and yellowing of your skin (jaundice), you should be seen immediately by your physician.


Osteoporosis, or weakening of the bones, is due to the reduction of minerals, notably calcium, in the bones. This softening of the bones could be due to malnutrition, malabsorption of nutrients from the small bowel or medications that interfere with calcium and vitamin D absorption (such as steroids). Regardless of the cause, people with Crohn’s and colitis are at higher risk of developing osteoporosis than the average population.

Those with osteoporosis have a higher risk of fractures so it is prudent to have a Bone Mineral Density (BMD) scan every year to enable early detection and treatment.

Skin Conditions

Erythema nodosum (EN), pyoderma gangrenosum (PG) and psoriasis are three skin conditions sometimes associated with Crohn’s and colitis.

EN appears as dark coloured (red or purple), painful bumps on the skin, usually on the shins. These lesions (bumps) tend to appear when bowel troubles are active, and go away when the bowel flare-ups subside.

PG lesions also typically appear on the legs, but can also be located close to an ileostomy site. They start off looking red and tender, gradually becoming more like a blister in appearance. They eventually do “ulcerate” or break open, seeping fluid from the sore. If large and “weepy”, PG lesions may require dressings.

People with Crohn’s disease appear to have a greater chance of developing psoriasis than the average person. Psoriasis is characterized by itchy, red patches covered with scales. Lesions can occur on the scalp, ears, elbows, knees, navel, genitalia or buttocks.

Ankylosing Spondylitis

Ankylosing Spondylitis (AS) is a severe form of arthritis that is more commonly associated with ulcerative colitis than with Crohn’s disease, although it can manifest with either. It may precede the onset of bowel symptoms by many years and at first, appears unrelated to Crohn’s or colitis.

Ankylosing spondylitis symptoms of pain and stiffness of the sacroiliac joints of the lower back do not coincide with flare-ups of bowel problems, and often appear independent of any GI disease. Surgery to remove the colon does not seem to relieve or cure AS. If the disease spreads up the spine, the bones may fuse together, causing permanent stiffness and lack of mobility.

A less severe form of arthritis of the sacroiliac joints is known as sacroiliitis. In this case, pain and stiffness develop in the lower back and possibly the hips. Fusion of the bones of the back does not occur as it does with ankylosing spondylitis.

Sores in the Mouth

Cankerous sores in the mouth can also afflict those with Crohn’s and colitis. When related to intestinal disease, these sores appear in clusters, can be quite large and painful, are present for a few weeks and usually coincide with a flare-up of Crohn’s or colitis.

learn more about complications of Ibd

Watch the short video below for an overview of complications of Crohn's and colitis. 

Click on the video below to learn from an expert gastroenterologist about extraintestinal manifestations of Crohn's and colitis, and how to manage these complications of IBD. This presentation was part of the Gutsy Learning Series. 

Watch the video below to hear from an expert in the field review complications of IBD how to best manage your symptoms during a flare. 

  • Canada has among the highest incidence rates of Crohn's and colitis in the world.
  • 1 in 140 Canadians lives with Crohn’s or colitis.
  • Families new to Canada are developing these diseases for the first time.
  • Incidence of Crohn’s in Canadian kids under 10 has doubled since 1995.
  • People are most commonly diagnosed before age 30.

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